Zseeker

Overview

Zseeker is an open-source Python tool designed for optimized detection of Z-DNA forming sequences in large genomic datasets. Z-DNA is an alternative left-handed DNA structure implicated in gene regulation, genome instability, and various biological processes.

Features

• High Performance: Optimized algorithms enable analysis of entire genomes
• Accuracy: Improved detection accuracy compared to previous methods
• Scalability: Designed to handle large-scale genomic datasets
• Easy to Use: Simple Python interface with clear documentation
• Open Source: Freely available for academic and commercial use

Technical Details

Zseeker implements advanced algorithms for identifying sequences capable of forming Z-DNA structures based on sequence composition and thermodynamic properties. The tool is optimized for both speed and accuracy, making it suitable for genome-wide analyses.

Use Cases

• Genome-wide Z-DNA mapping
• Regulatory element identification
• Genome stability studies
• Comparative genomics of non-B DNA structures
• Disease-associated variant analysis

Publications

Wang, G., Mouratidis, I., Provatas, K., et al. (2025). ZSeeker: an optimized algorithm for Z-DNA detection in genomic sequences. Briefings in Bioinformatics, 26(3).