ZSeeker: an optimized algorithm for Z-DNA detection in genomic sequences
Jan 2025·
,·
1 min read
G. wang
Equal contribution
Ioannis Mouratidis
Equal contribution
,K. provatas
Et al.
Abstract
Z-DNA is an alternative left-handed DNA structure implicated in gene regulation and genome instability. We developed ZSeeker, an optimized Python tool for detecting Z-DNA forming sequences in large genomic datasets with improved speed and accuracy.
Type
Publication
Briefings in Bioinformatics, 26(3)
ZSeeker provides researchers with a fast and accurate tool for identifying Z-DNA forming sequences across entire genomes, facilitating studies of genome regulation and stability.
Authors
Authors
Ioannis Mouratidis
(he/him)
Research Engineer
Research engineer focused on AI safety, alignment, and AIxBio security. I study how
capabilities and values emerge during model training and build scalable interventions to align
frontier models, drawing on deep expertise in biosecurity and biological foundation models.
38 publications (12 first or senior author) and 3 patents in large-scale data analysis and ML
for biology; co-founded an AI-driven cancer-diagnostics startup and authored grants securing
$4M+ in competitive funding.
Authors
Authors