https://ioannis-mouratidis.github.io/tags/Z-DNA/Z-DNAHugo Blox Builder (https://hugoblox.com)en-usWed, 01 Jan 2025 00:00:00 +0000https://ioannis-mouratidis.github.io/media/icon_hu_899445b689d8f445.pnghttps://ioannis-mouratidis.github.io/tags/Z-DNA/https://ioannis-mouratidis.github.io/projects/zseeker/Wed, 01 Jan 2025 00:00:00 +0000https://ioannis-mouratidis.github.io/projects/zseeker/<h2 id="overview">Overview</h2> <p>Zseeker is an open-source Python tool designed for optimized detection of Z-DNA forming sequences in large genomic datasets. Z-DNA is an alternative left-handed DNA structure implicated in gene regulation, genome instability, and various biological processes.</p> <h2 id="features">Features</h2> <ul> <li><strong>High Performance</strong>: Optimized algorithms enable analysis of entire genomes</li> <li><strong>Accuracy</strong>: Improved detection accuracy compared to previous methods</li> <li><strong>Scalability</strong>: Designed to handle large-scale genomic datasets</li> <li><strong>Easy to Use</strong>: Simple Python interface with clear documentation</li> <li><strong>Open Source</strong>: Freely available for academic and commercial use</li> </ul> <h2 id="technical-details">Technical Details</h2> <p>Zseeker implements advanced algorithms for identifying sequences capable of forming Z-DNA structures based on sequence composition and thermodynamic properties. The tool is optimized for both speed and accuracy, making it suitable for genome-wide analyses.</p> <h2 id="use-cases">Use Cases</h2> <ul> <li>Genome-wide Z-DNA mapping</li> <li>Regulatory element identification</li> <li>Genome stability studies</li> <li>Comparative genomics of non-B DNA structures</li> <li>Disease-associated variant analysis</li> </ul> <h2 id="publications">Publications</h2> <p>Wang, G., Mouratidis, I., Provatas, K., et al. (2025). ZSeeker: an optimized algorithm for Z-DNA detection in genomic sequences. <em>Briefings in Bioinformatics, 26</em>(3).</p>https://ioannis-mouratidis.github.io/publications/zseeker-2025/Wed, 01 Jan 2025 00:00:00 +0000https://ioannis-mouratidis.github.io/publications/zseeker-2025/<p>ZSeeker provides researchers with a fast and accurate tool for identifying Z-DNA forming sequences across entire genomes, facilitating studies of genome regulation and stability.</p>